Structure of PDB 6xqv Chain B

Receptor sequence
>6xqvB (length=327) Species: 485 (Neisseria gonorrhoeae) [Search protein sequence]
DMLSLDQRIQTLAYEELNKAVEYHQAKAGTVVVLDARTGEILALANTPGG
RNRAVTDMIEPGAAIKPFVIAKALDAGKTDLNERLNTQPYKIGPSPVRDT
HVYPSLDVRGIMQKSSNVGTSKLSARFGAEEMYDFYHELGIGVRMHSGFP
GETAGLLRNWRRWRPIEQATMSFGYGLQLSLLQLARAYTALTHDGVLLPL
SFEKQAVAPQGKRIFKESTAREVRNLMVSVTEPGGTGTAGAVDGFDVGAK
TGTARKFVNGRYADNKHVATFIGFAPAKNPRVIVAVTIDEPTAHGYYGGV
VAGPPFKKIMGGSLNILGISPTKPLTA
3D structure
PDB6xqv Mutations in PBP2 from ceftriaxone-resistant Neisseria gonorrhoeae alter the dynamics of the beta 3-beta 4 loop to favor a low-affinity drug-binding state.
ChainB
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9F2 B E307 G309 A310 F420 G421 Y422 T483 T498 G499 T500 A501 R502 Y544 G546 E60 G62 A63 F173 G174 Y175 T236 T251 G252 T253 A254 R255 Y297 G299
BS02 9F2 B H348 V349 Y350 P351 H101 V102 Y103 P104
Gene Ontology
Molecular Function
GO:0008658 penicillin binding

View graph for
Molecular Function
External links
PDB RCSB:6xqv, PDBe:6xqv, PDBj:6xqv
PDBsum6xqv
PubMed34529975
UniProtP08149|PBP2_NEIGO Probable peptidoglycan D,D-transpeptidase PenA (Gene Name=penA)

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