Structure of PDB 6xog Chain B

Receptor sequence
>6xogB (length=500) Species: 9606 (Homo sapiens) [Search protein sequence]
PRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNL
NRQFLFQKKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFR
QFILVMNALDNRAARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTE
CYECHPKPTFPGCTIRNTPSEPIHCIVWAKYLFNQLFGEEDADQEVSPDR
ADPEAAWEPTEAEATKEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRK
RKPPVPLDWAEVQSQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKELI
WDKDDPSAMDFVTSAANLRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAV
IAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLVPCALDPPNPNCYV
CASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDVQIEDGTILISSEE
ETENNKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGKDVEFEVVG
3D structure
PDB6xog Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.
ChainB
Resolution1.98 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D117 C173 T174 R176
Catalytic site (residue number reindexed from 1) D110 C163 T164 R166
Enzyme Commision number 2.3.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C158 C161 C441 C444 C151 C154 C398 C401
BS02 VAY B D48 L49 K72 S95 I96 M97 A115 D117 N118 D41 L42 K65 S88 I89 M90 A108 D110 N111
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008641 ubiquitin-like modifier activating enzyme activity
GO:0016740 transferase activity
GO:0019948 SUMO activating enzyme activity
GO:0032183 SUMO binding
GO:0044388 small protein activating enzyme binding
GO:0044390 ubiquitin-like protein conjugating enzyme binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0016925 protein sumoylation
GO:0033235 positive regulation of protein sumoylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0031510 SUMO activating enzyme complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xog, PDBe:6xog, PDBj:6xog
PDBsum6xog
PubMed33631934
UniProtQ9UBT2|SAE2_HUMAN SUMO-activating enzyme subunit 2 (Gene Name=UBA2)

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