Structure of PDB 6xgu Chain B

Receptor sequence
>6xguB (length=134) Species: 9606 (Homo sapiens) [Search protein sequence]
SNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHE
HKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDI
CQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWS
3D structure
PDB6xgu KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H139 C165 C168 C184 H85 C111 C114 C130
BS02 ZN B C152 C155 H173 C176 C98 C101 H119 C122
Gene Ontology
Biological Process
GO:0007165 signal transduction

View graph for
Biological Process
External links
PDB RCSB:6xgu, PDBe:6xgu, PDBj:6xgu
PDBsum6xgu
PubMed33608534
UniProtP04049|RAF1_HUMAN RAF proto-oncogene serine/threonine-protein kinase (Gene Name=RAF1)

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