Structure of PDB 6xbb Chain B

Receptor sequence

>6xbbB (length=416) Species: 463191 (Streptomyces sviceus ATCC 29083)

TVHDFVGIGLGPFNLGLACLTEPIDELDGIFLESKPDFEWHAGMFLDGAH
LQTPFMSDLVTLADPTSPYSFLNYLKEKGRLYSFYIRENFYPLRVEYDDY
CRWAANKLSSIRFGTTVTEVRYEDDLYVVTTSAGDVYRARHLVLGTGTPP
YIPEACQGLDGDFIHNSRYVQHRSELVKKESITIVGSGQSAAEIYQDLLG
EIDVHGYRLNWVTRSPRFFPLEYTKLTLEMTSPEYIDYYRELPEATRYRL
TAEQKGLFKGIDGDLINEIFDLLYQKNLAGPVPTRLLTNSSLNSARHENG
TYTLAFRQEEQGKDFEIESQGLVLATGYKYAEPEFLAPVKDRLVYDSQGN
FDVSRAYAIDVTGRGVFLQNAGVHTHSITSPDLGMGAYRNSCIIRELLGT
EYYPVEKTIAFQEFSV

3D structure

• PDB: 6xbb Characterization of a broadly specific cadaverine N-hydroxylase involved in desferrioxamine B biosynthesis in Streptomyces sviceus.
• Chain: B
• Resolution: 2.366 Å

Enzymatic activity

• Enzyme Commision number: 1.14.13.59: L-lysine N(6)-monooxygenase (NADPH).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	B	G18 G20 P21 F22 E42 S43 K44 W49 H50 L60 Q61 V126 G154 T155 G156 Y337 N379 P390 D391 L392	G9 G11 P12 F13 E33 S34 K35 W40 H41 L51 Q52 V117 G145 T146 G147 Y328 N370 P381 D382 L383
BS02	NAP	B	Q61 R103 P162 G195 S196 G197 Q198 S199 R223 S224 K264 F267 K268 L301 A334 T335	Q52 R94 P153 G186 S187 G188 Q189 S190 R214 S215 K255 F258 K259 L292 A325 T326

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0047091 L-lysine 6-monooxygenase (NADPH) activity

Biological Process

• GO:0009058 biosynthetic process

External links

• PDB: RCSB:6xbb, PDBe:6xbb, PDBj:6xbb
• PDBsum: 6xbb
• PubMed: 33784308
• UniProt: B5HNG5