Structure of PDB 6x5s Chain B

Receptor sequence
>6x5sB (length=466) Species: 9606 (Homo sapiens) [Search protein sequence]
LGKDHEILRRRIENGAKELWFFLQSELKKLKNLEGNELQRHADEFLLDLG
HHERSIMTDLYYLSQTDGAGDWREKEAKDLTELVQRRITYLQNPKDCSKA
KKLVCNINKGCGYGCQLHHVVYCFMIAYGTQRTLILESQNWRYATGGWET
VFRPVSETCTDRSGISTGHWSGEVKDKNVQVVELPIVDSLHPRPPYLPLA
VPEDLADRLVRVHGDPAVWWVSQFVKYLIRPQPWLEKEIEEATKKLGFKH
PVIGVHVRRTDKVGTEAAFHPIEEYMVHVEEHFQLLARRMQVDKKRVYLA
TDDPSLLKEAKTKYPNYEFISDNSISWSAGLHNRYTENSLRGVILDIHFL
SQADFLVCTFSSQVCRVAYEIMQTLHPDASANFHSLDDIYYFGGQNAHNQ
IAIYAHQPRTADEIPMEPGDIIGVAGNHWDGYSKGVNRKLGRTGLYPSYK
VREKIETVKYPTYPEA
3D structure
PDB6x5s Characterizing human alpha-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases.
ChainB
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.68: glycoprotein 6-alpha-L-fucosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP B G219 Y220 G221 Y250 H363 R365 K369 A407 T408 A436 R441 G449 V450 D453 S469 Q470 G112 Y113 G114 Y143 H256 R258 K262 A300 T301 A329 R334 G342 V343 D346 S362 Q363
External links
PDB RCSB:6x5s, PDBe:6x5s, PDBj:6x5s
PDBsum6x5s
PubMed33004438
UniProtQ9BYC5|FUT8_HUMAN Alpha-(1,6)-fucosyltransferase (Gene Name=FUT8)

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