Structure of PDB 6ws1 Chain B

Receptor sequence
>6ws1B (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
DSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQT
FATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWL
QEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQP
LGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLI
GALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQT
GVDDVKGVFFAWAQKV
3D structure
PDB6ws1 Transition-State Analogues of PhenylethanolamineN-Methyltransferase.
ChainB
Resolution2.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.28: phenylethanolamine N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U87 B Y27 Y35 Y40 S80 T83 Y85 D101 F102 L103 I157 D158 V159 A181 F182 V187 E219 Y222 Y13 Y21 Y26 S66 T69 Y71 D87 F88 L89 I143 D144 V145 A167 F168 V173 E205 Y208
Gene Ontology
Molecular Function
GO:0004603 phenylethanolamine N-methyltransferase activity
GO:0005515 protein binding
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0042418 epinephrine biosynthetic process
GO:0042423 catecholamine biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ws1, PDBe:6ws1, PDBj:6ws1
PDBsum6ws1
PubMed32702980
UniProtP11086|PNMT_HUMAN Phenylethanolamine N-methyltransferase (Gene Name=PNMT)

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