Structure of PDB 6wok Chain B

Receptor sequence
>6wokB (length=230) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEYDPTRSMMGLLTNLADRELVHMINW
AKRVPGFVDLTSHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLL
DRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYT
FSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILS
HIRHMSNKGMEHLYSMKVVPSYDLLLEMLD
3D structure
PDB6wok Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer.
ChainB
Resolution2.309 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U6D B L346 T347 A350 D351 E353 L387 L391 R394 F404 M421 I424 G521 L525 V534 P535 L36 T37 A40 D41 E43 L77 L81 R84 F94 M111 I114 G209 L213 V219 P220 MOAD: ic50=1.6nM
BindingDB: IC50=0.079433nM
External links
PDB RCSB:6wok, PDBe:6wok, PDBj:6wok
PDBsum6wok
PubMed32551022
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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