Structure of PDB 6woj Chain B

Receptor sequence

>6wojB (length=170) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]

VNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGA
LNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNK
GEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVY
LAVFDKNLYDKLVSSFLEMK

3D structure

PDB

6woj The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase.

Chain

Resolution

2.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	APR	B	I23 A38 N40 H45 G46 G48 V49 A50 L126 S128 A129 G130 I131 F132 A154 F156	I21 A36 N38 H43 G44 G46 V47 A48 L124 S126 A127 G128 I129 F130 A152 F154	MOAD: Kd=16.8uM

External links

PDB	RCSB:6woj, PDBe:6woj, PDBj:6woj
PDBsum	6woj
PubMed	33158944
UniProt	P0DTD1\|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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