Structure of PDB 6wmq Chain B

Receptor sequence
>6wmqB (length=197) Species: 9606 (Homo sapiens) [Search protein sequence]
HLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLS
QHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAG
DLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQE
TLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV
3D structure
PDB6wmq Structural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERB beta.
ChainB
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B V413 V417 K421 Q434 V435 L438 K439 L572 K576 V33 V37 K41 Q54 V55 L58 K59 L192 K196
BS02 HEM B L382 V383 C384 P385 M386 W402 F405 F409 F443 G480 L482 L483 M486 H568 F575 L2 V3 C4 P5 M6 W22 F25 F29 F63 G100 L102 L103 M106 H188 F195
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6wmq, PDBe:6wmq, PDBj:6wmq
PDBsum6wmq
PubMed33571111
UniProtQ14995|NR1D2_HUMAN Nuclear receptor subfamily 1 group D member 2 (Gene Name=NR1D2)

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