Structure of PDB 6wi8 Chain B

Receptor sequence
>6wi8B (length=199) Species: 9606 (Homo sapiens) [Search protein sequence]
TWELSLYELQRTPQEAITDGLEIVVSPRSLHSELMCPICLDMLKNTMTTK
ECLHRFCADCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYP
TTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIVRYLETSKYC
PICDVQVHKTRPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRDFYAAHP
3D structure
PDB6wi8 Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.
ChainB
Resolution3.092 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
5.-.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C1018 C1021 C1039 C1042 C115 C118 C136 C139
BS02 ZN B C1034 H1036 C1053 C131 H133 C150
BS03 ZN B C67 H69 C87 C90 C52 H54 C72 C75
BS04 ZN B C51 C54 C72 C75 C36 C39 C57 C60
External links
PDB RCSB:6wi8, PDBe:6wi8, PDBj:6wi8
PDBsum6wi8
PubMed34155404
UniProtP35226|BMI1_HUMAN Polycomb complex protein BMI-1 (Gene Name=BMI1);
Q99496|RING2_HUMAN E3 ubiquitin-protein ligase RING2 (Gene Name=RNF2)

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