Structure of PDB 6wgx Chain B

Receptor sequence
>6wgxB (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB6wgx Selective N-Terminal BET Bromodomain Inhibitors by Targeting Non-Conserved Residues and Structured Water Displacement*.
ChainB
Resolution1.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U0D B W81 P82 F83 V87 L92 Y97 M105 M132 N140 I146 W40 P41 F42 V46 L51 Y56 M64 M91 N99 I105 MOAD: ic50=0.15uM
External links
PDB RCSB:6wgx, PDBe:6wgx, PDBj:6wgx
PDBsum6wgx
PubMed32975004
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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