Structure of PDB 6wge Chain B

Receptor sequence
>6wgeB (length=490) Species: 9606 (Homo sapiens) [Search protein sequence]
MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLS
DEFSHLRPEQRLALLHEGTGPRVISAFVEIIFDNSDNRLPIDKEEVSLRR
VIGAKKDQYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATA
PDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERL
HTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKKKEECMKKIREL
GSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQ
KEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQK
LVPGGKATLVMKKGQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVALAL
IFAIQKCDPAPFYLFDQIDQALDAQHRKAVSDMIMELAVHAQFITTTFRP
ELLESADKFYGVKFRNKVSHIDVITAEMAKDFVEDDTTHG
3D structure
PDB6wge Cryo-EM structure of the human cohesin-NIPBL-DNA complex.
ChainB
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP B Q1114 L1115 S1116 Q387 L388 S389
BS02 ANP B R12 N34 G35 G37 K38 S39 N40 Q141 R12 N34 G35 G37 K38 S39 N40 Q141
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036033 mediator complex binding
GO:0046982 protein heterodimerization activity
GO:0048487 beta-tubulin binding
GO:0070840 dynein complex binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006275 regulation of DNA replication
GO:0006281 DNA repair
GO:0007062 sister chromatid cohesion
GO:0007064 mitotic sister chromatid cohesion
GO:0019827 stem cell population maintenance
GO:0034087 establishment of mitotic sister chromatid cohesion
GO:0034089 establishment of meiotic sister chromatid cohesion
GO:0051276 chromosome organization
GO:0051301 cell division
GO:0051321 meiotic cell cycle
GO:0090307 mitotic spindle assembly
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0000800 lateral element
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0008278 cohesin complex
GO:0016363 nuclear matrix
GO:0030892 mitotic cohesin complex
GO:0030893 meiotic cohesin complex
GO:0097431 mitotic spindle pole

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wge, PDBe:6wge, PDBj:6wge
PDBsum6wge
PubMed32409525
UniProtQ9UQE7|SMC3_HUMAN Structural maintenance of chromosomes protein 3 (Gene Name=SMC3)

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