Structure of PDB 6wfo Chain B

Receptor sequence
>6wfoB (length=152) Species: 9606 (Homo sapiens) [Search protein sequence]
GSRIELGDVTPHNIKQLKRLNQVIFPVSYNDKFYKDVLEVGELAKLAYFN
DIAVGAVCCRVDHSQNQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEK
DGTFDNIYLHVQISNESAIDFYRKFGFEIIETKKNYYKRIEPADAHVLQK
NL
3D structure
PDB6wfo Characterization of SpecificN-alpha-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
ChainB
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.258: N-terminal methionine N(alpha)-acetyltransferase NatE.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACO B I26 F27 I74 M75 T76 L77 G78 C79 R84 R85 G87 G89 T90 N117 S119 A120 D122 F123 K126 I24 F25 I72 M73 T74 L75 G76 C77 R82 R83 G85 G87 T88 N115 S117 A118 D120 F121 K124 BindingDB: Kd=18nM
BS02 U3Y B F27 P28 V29 Y31 Y73 M75 H112 Y138 Y139 K140 F25 P26 V27 Y29 Y71 M73 H110 Y136 Y137 K138 MOAD: Kd=470nM
Gene Ontology
Molecular Function
GO:0004596 peptide alpha-N-acetyltransferase activity
GO:0005515 protein binding
GO:0010485 histone H4 acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0061733 peptide-lysine-N-acetyltransferase activity
GO:0120518 peptide-methionine-alpha-N-acetyltransferase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006474 N-terminal protein amino acid acetylation
GO:0007064 mitotic sister chromatid cohesion
GO:0034087 establishment of mitotic sister chromatid cohesion
GO:0071962 mitotic sister chromatid cohesion, centromeric
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031415 NatA complex
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wfo, PDBe:6wfo, PDBj:6wfo
PDBsum6wfo
PubMed32550998
UniProtQ9GZZ1|NAA50_HUMAN N-alpha-acetyltransferase 50 (Gene Name=NAA50)

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