Structure of PDB 6we4 Chain B

Receptor sequence
>6we4B (length=183) Species: 9606 (Homo sapiens) [Search protein sequence]
QQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQAK
KKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSAVAYGKGTYFAVN
ANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTD
LYDTVTDNVHHPSLFVAFYDYQAYPEYLITFRK
3D structure
PDB6we4 A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants.
ChainB
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TYG B H1682 G1683 D1685 Y1714 S1722 T1726 Y1727 R1729 H69 G70 D72 Y96 S104 T108 Y109 R111
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

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Molecular Function
External links
PDB RCSB:6we4, PDBe:6we4, PDBj:6we4
PDBsum6we4
PubMed33705687
UniProtQ460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (Gene Name=PARP14)

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