Structure of PDB 6wcw Chain B

Receptor sequence
>6wcwB (length=176) Species: 9606 (Homo sapiens) [Search protein sequence]
VLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRL
VTMQIWDTAGLERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEF
LIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSA
KEAINVEQAFQTIARNALKQETEVEL
3D structure
PDB6wcw Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP B G18 G20 K21 T22 S23 F33 N35 Y37 T40 N125 K126 D128 L129 S155 A156 K157 G12 G14 K15 T16 S17 F27 N29 Y31 T34 N119 K120 D122 L123 S149 A150 K151
BS02 MG B T22 T40 T16 T34
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:6wcw, PDBe:6wcw, PDBj:6wcw
PDBsum6wcw
PubMed32632011
UniProtP51149|RAB7A_HUMAN Ras-related protein Rab-7a (Gene Name=RAB7A)

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