Structure of PDB 6wb7 Chain B

Receptor sequence
>6wb7B (length=293) Species: 134676 (Actinoplanes sp. SE50/110) [Search protein sequence]
HTDVLVLGGAGVDTIAYVPELPLPFQDSYVVAAIEPRAGQTGDNVALGLH
TLGLRTMHVDVLGDDPEGDLVRAFHTRHGLPFAALPTAAGTKRAVNLVGP
DGRRLSLWDGSREAEEDRYPAALIAAHTAHARHVHVCITPPGQHVFGQLN
DLPVTVSTDLHNWDGAYEGFEVYAFNADLVFLSATALTDVAATMRRVIDR
GRARLVVATDGAHGGSVLVRGETEVRRYAAVAPEAPVVDSNGAGDAFVSG
FLFGHLAGEPLETCLRYGAIAGAYACTIPATRAGAIDRAALLR
3D structure
PDB6wb7 The human microbiome encodes resistance to the antidiabetic drug acarbose.
ChainB
Resolution2.44 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.187: acarbose 7(IV)-phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC B G113 E116 G110 E113
BS02 AC1 B D16 Q43 T44 N99 S109 W111 N165 D248 D13 Q40 T41 N96 S106 W108 N162 D245
BS03 ANP B R107 T212 G214 G217 Y231 V234 P236 G245 G247 D248 A272 C279 R104 T209 G211 G214 Y228 V231 P233 G242 G244 D245 A269 C276
Gene Ontology
Molecular Function
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0016310 phosphorylation
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wb7, PDBe:6wb7, PDBj:6wb7
PDBsum6wb7
PubMed34819672
UniProtQ8RMD4|ACBK_ACTS5 Acarbose 7(IV)-phosphotransferase (Gene Name=acbK)

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