Structure of PDB 6w91 Chain B

Receptor sequence
>6w91B (length=160) Species: 37124 (Chikungunya virus) [Search protein sequence]
APSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSAT
PVGTAKTVMCGTYPVIHAVGPNFSNYSESEGDRELAAAYREVAKEVTRLG
VNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEK
KISEAIQMRT
3D structure
PDB6w91 Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design.
ChainB
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.7.7.-
2.7.7.19: polynucleotide adenylyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
3.1.3.84: ADP-ribose 1''-phosphate phosphatase.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.1.74: mRNA 5'-phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TJP B A22 A23 G70 L109 S110 G112 V113 Y114 A22 A23 G70 L109 S110 G112 V113 Y114
External links
PDB RCSB:6w91, PDBe:6w91, PDBj:6w91
PDBsum6w91
PubMed33482665
UniProtQ8JUX6|POLN_CHIKS Polyprotein P1234

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