Structure of PDB 6w8f Chain B

Receptor sequence

>6w8fB (length=281) Species: 10090 (Mus musculus)

SDSAINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPQEISQRTTIVIQR
EKFLRAHPCVSDQELDELIQQIVAAINAGIIPLGASSNQVSHWDLGSSFF
FAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTI
FGKGIAKVEDTFIKWVSQTKIRIISTIIFILFGCVLFVALPAVIFKHIEG
WSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYF
AAVLSMIGDWLRVIAKKTKEAVGEFRAHAAE

3D structure

• PDB: 6w8f K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
• Chain: B
• Resolution: 3.4 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	K	B	T142 I143 G144 T251 I252 G253	T108 I109 G110 T216 I217 G218
BS02	K	B	I143 G144 F145 I252 G253 F254	I109 G110 F111 I217 G218 F219
BS03	K	B	T142 T251	T108 T216
BS04	K	B	G144 F145 G146 G253 F254 G255	G110 F111 G112 G218 F219 G220
BS05	Q6F	B	S131 F134 G137 T138 F145 A259 G260 G261 K271 W275 I278	S97 F100 G103 T104 F111 A224 G225 G226 K236 W240 I243

Gene Ontology

Molecular Function

• GO:0005267 potassium channel activity

Biological Process

• GO:0071805 potassium ion transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6w8f, PDBe:6w8f, PDBj:6w8f
• PDBsum: 6w8f
• PubMed: 33127683
• UniProt: P97438|KCNK2_MOUSE Potassium channel subfamily K member 2 (Gene Name=Kcnk2)