Structure of PDB 6w6v Chain B

Receptor sequence

>6w6vB (length=780) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

KQLQLAMHNSKAASSTRIFQALPRKLRRRTASHNVRRIPKRMRNRALREM
RKSDKAHGLNAKQLYKARMSIKLLRLASKSTSMKLSMPPEVTSSNCHVRQ
KIKTLKRMIKESSTANPNIKLLNNRMGSYDCTGVNELAPIPKGRVKYTKR
QKHFAWLPTHIWNAKRSHMMKRWGYQMVWAPTQKCFKLTHRLGGDTCSSD
GALCMDSSYIGTIIVKDKSNDSEGDFLKSIIGKLTAERANLRKYREGQVL
FQGLIYSFNEENGEDSTKPLGPCDVFWVQKDTAIIRLHPSIYTQVFNILL
QHKEKLTVQDCRYSLASVTLKGAKALESLASCLRSTEYSKSFEQFKMVSM
ITDHNALPQRCTFAFEAIDPRHLAAPKKLNDSQRKTVNSDDILSLHENYP
QDEINAVFNELCDPESRTQSYNNQNTLKEISARRYKLLTATPNSINKTTV
PFKESDDPSIPLVIIRRLKTRDWIVVLPWFWLLPLWHLLNRIPRMYHIGL
RQFQQIQYENKQLYFPDDYPFTQLGYIENSFYKKEASKTKWDRKPMGKRI
NFEKIKDIHNTKLPAYSGEIGDFFSSDWRFLQILRNGIDYLQRNDKTLEL
MDSKKTGQQGVRDINCVNDVLEFCKDYEAKTKAMSLSIEENIPVALCKNR
KCQFSSSFSLTFFPRCIIAVSCTLLERGHPKDNARIYQVPEKDLEHWLQL
AKGVYRPNGRKDHDLKIPLPEVHDLIGFITSGTYHLNCGNGMGIGFIDHH
AAIRQPTRYVLIRNVGTNTYRLGEWSKISV

3D structure

PDB

6w6v Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP.

Chain

Resolution

3.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.26.5: ribonuclease P.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	B	R87 Q90 L92 P93 R94 R97 R98 R99 S102 V105 R106 R111 R115 Y148 M152 K155 L156 R158 L159 K162 S163 S165 V174 T175 N178 C179 H180 V181 N199 R208 M209 G210 K225 V228 K229 K232 R233 A247 K248 R249 H251 T265 K267 F269 K270 R274 D278 T279 C280 F425 K429 D436 A458 K460 N463 L510 K511 S514 I528 H570 R626 K627 P628 M629 K631 E636 K637 R772 G773 H808 Y829 L831 T864	R17 Q20 L22 P23 R24 R27 R28 R29 S32 V35 R36 R41 R45 Y65 M69 K72 L73 R75 L76 K79 S80 S82 V91 T92 N95 C96 H97 V98 N116 R125 M126 G127 K142 V145 K146 K149 R150 A164 K165 R166 H168 T182 K184 F186 K187 R191 D195 T196 C197 F342 K346 D353 A375 K377 N380 L427 K428 S431 I445 H487 R543 K544 P545 M546 K548 E553 K554 R677 G678 H713 Y734 L736 T769

Gene Ontology

	Molecular Function
GO:0000171	ribonuclease MRP activity
GO:0003723	RNA binding
GO:0004526	ribonuclease P activity
GO:0005515	protein binding
GO:0016787	hydrolase activity

	Biological Process
GO:0000294	nuclear-transcribed mRNA catabolic process, RNase MRP-dependent
GO:0000460	maturation of 5.8S rRNA
GO:0001682	tRNA 5'-leader removal
GO:0006364	rRNA processing
GO:0008033	tRNA processing
GO:0034965	intronic box C/D snoRNA processing

	Cellular Component
GO:0000172	ribonuclease MRP complex
GO:0005634	nucleus
GO:0005655	nucleolar ribonuclease P complex
GO:0005697	telomerase holoenzyme complex
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6w6v, PDBe:6w6v, PDBj:6w6v
PDBsum	6w6v
PubMed	32651392
UniProt	P41812\|POP1_YEAST Ribonucleases P/MRP protein subunit POP1 (Gene Name=POP1)

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