Structure of PDB 6w6h Chain B

Receptor sequence
>6w6hB (length=629) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
QALQKYSTDLTARAREGKLDPVIGRDNEIRRVVQVLSRRTKNNPVLIGEP
GVGKTAIVEGLAQRIVAGDVPESLRDKTIVALDLGSMVAGSKYRGEFEER
LKAVLDDIKNSAGQIITFIDELHTIVGAGADAGNMIKPMLARGELRLVGA
TTLDEYRKHIEKDAALERRFQQVYVGEPSVEDTIGILRGLKDRYEVHHGV
RITDSALVAAATLSDRYITARFLPDKAIDLVDEAASRLRMEIDSRPVEID
EVERLVRRLEIEEMALSKEEDEASAERLAKLRSELADQKEKLAELTTRWQ
NEKNAIEIVRDLKKEEVGPDDIADVVSAWTGIPAGRLLEGETAKLLRMED
ELGKRVIGQKAAVTAVSDAVRRSRAGVSDPNRPTGAFMFLGPTGVGKTEL
AKALADFLFDDERAMVRIDMSEYGEKHTVARLIGAPPGYVGYEAGGQLTE
AVRRRPYTVVLFDEIEKAHPDVFDVLLQVLDEGRLTDGHGRTVDFRNTIL
ILTSNLGSGGSAEQVLAAVRATFKPEFINRLDDVLIFEGLNPEELVRIVD
IQLAQLGKRLAQRRLQLQVSLPAKRWLAQRGFDPVYGARPLRRLVQQAIG
DQLAKMLLAGQVHDGDTVPVNVSPDADSL
3D structure
PDB6w6h Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system.
ChainB
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B K250 Y251 Y655 V656 K92 Y93 Y439 V440
BS02 AGS B R332 R333 R168 R169
BS03 AGS B I573 T609 G610 V611 G612 K613 T614 E615 R805 R808 I357 T393 G394 V395 G396 K397 T398 E399 R589 R592
BS04 AGS B I181 G211 K212 I350 I23 G53 K54 I186
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0009408 response to heat
GO:0034605 cellular response to heat
GO:0042026 protein refolding
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6w6h, PDBe:6w6h, PDBj:6w6h
PDBsum6w6h
PubMed34038719
UniProtP9WPD1|CLPB_MYCTU Chaperone protein ClpB (Gene Name=clpB)

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