Structure of PDB 6w3j Chain B

Receptor sequence
>6w3jB (length=218) Species: 9606 (Homo sapiens) [Search protein sequence]
TLRSITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKE
VLQISSDGNTITIYYPNFPLADRPPSPTDNISRYSFDNLPEKYWRKYQYA
SRFVQLVRSKSPKITYFTRYAKCILMENSPGADFEVWFYDGVKIHKTEDF
IQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICLALESIISEE
ERKTRSAPFFPIIIGRKP
3D structure
PDB6w3j Structural and Functional Analyses of the FAM46C/Plk4 Complex.
ChainB
Resolution4.385 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 peptide B K600 I602 R603 Q604 T606 K607 K608 K685 Y688 F692 K699 K711 K15 I17 R18 Q19 T21 K22 K23 K96 Y99 F103 K110 K122
External links
PDB RCSB:6w3j, PDBe:6w3j, PDBj:6w3j
PDBsum6w3j
PubMed32433990
UniProtO00444|PLK4_HUMAN Serine/threonine-protein kinase PLK4 (Gene Name=PLK4)

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