Structure of PDB 6vzs Chain B

Receptor sequence

>6vzsB (length=401) Species: 10090 (Mus musculus)

KKRLVINLSNCRYDSVRRAAQQYGLREAGDNDDWTLYWTDYSVSLERVME
MKSYQKINHFPGMSEICRKDLLARNMSRMLKLFPKDFHFFPRTWCLPADW
GDLQTYSRTRKNKTYICKPDSGARGRGIFITRSVKEIKPGEDMICQLYIS
KPFIIDGFKFDLRVYVLVTSCDPLRVFVYNEGLARFATTSYSHPNLDNLD
EICMHLTNYSINKHSSNFVQDAFSGSKRKLSTFNSYMKTHGYDVEQIWRG
IEDVIIKTLISAHPVIKHNYHTCFPSHTLNSACFEILGFDILLDRKLKPW
LLEVNISPSFSTDSKLDKEVKDSLLYDALVLINLGNCDKKKVLEEERQRG
RFLQNREIRLEEVKGFQAMRLQKTEEYEKKNCGGFRLIYPGLNLEKYDKF
F

3D structure

• PDB: 6vzs Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.
• Chain: B
• Resolution: 2.66 Å

Enzymatic activity

• Enzyme Commision number: 6.3.2.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	B	K125 I172 K174 A179 G181 I184 Q202 Y204 I205 K215 D217 T263 N264 L358 E359	K69 I116 K118 A123 G125 I128 Q146 Y148 I149 K159 D161 T207 N208 L302 E303
BS02	S3A	B	R180 R219 R241 N264 Y265 S266 K283 N361 S363 S365 K377	R124 R163 R185 N208 Y209 S210 K227 N305 S307 S309 K321
BS03	MG	B	A179 E359 N361	A123 E303 N305
BS04	MG	B	D346 E359	D290 E303

Gene Ontology

Biological Process

• GO:0036211 protein modification process

External links

• PDB: RCSB:6vzs, PDBe:6vzs, PDBj:6vzs
• PDBsum: 6vzs
• PubMed: 32747782
• UniProt: A4Q9E8|TTLL6_MOUSE Tubulin polyglutamylase TTLL6 (Gene Name=Ttll6)