Structure of PDB 6vzl Chain B

Receptor sequence
>6vzlB (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTKSPFVIYDMNSLMMGEDK
IEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHE
IIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKF
NALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLN
HPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETHPLLQEIYKDL
3D structure
PDB6vzl Structural mechanism underlying ligand binding and activation of PPAR gamma.
ChainB
Resolution2.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EDK B R280 G284 C285 F287 R288 S289 L330 I341 S342 E343 R56 G60 C61 F63 R64 S65 L106 I117 S118 E119 BindingDB: EC50=130nM,Ki=0.049700nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6vzl, PDBe:6vzl, PDBj:6vzl
PDBsum6vzl
PubMed33713599
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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