Structure of PDB 6vz1 Chain B

Receptor sequence

>6vz1B (length=411) Species: 9606 (Homo sapiens) [Search protein sequence]

WELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGI
LVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQA
GLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRD
VNSWCRRARAKAASAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRS
PRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRII
ERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESV
TYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVL
MYVHDYYVLNY

3D structure

PDB

6vz1 Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme.

Chain

Resolution

3.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.3.1.20: diacylglycerol O-acyltransferase.
2.3.1.76: retinol O-fatty-acyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	6OU	B	R86 L98 A101 F104 R280 R281 F287	R23 L35 A38 F41 R210 R211 F217
BS02	6OU	B	I88 W91	I25 W28
BS03	6OU	B	F76 S78 N451 Y452	F13 S15 N381 Y382
BS04	6OU	B	L89 C92 V93 L291 L295 Y339	L26 C29 V30 L221 L225 Y269
BS05	3VV	B	P191 L195 Q375 H382 I386 Y390 R404 S411 H415 Y476	P128 L132 Q305 H312 I316 Y320 R334 S341 H345 Y406

Gene Ontology

	Molecular Function
GO:0003846	2-acylglycerol O-acyltransferase activity
GO:0004144	diacylglycerol O-acyltransferase activity
GO:0005515	protein binding
GO:0008374	O-acyltransferase activity
GO:0016746	acyltransferase activity
GO:0042802	identical protein binding
GO:0050252	retinol O-fatty-acyltransferase activity

	Biological Process
GO:0006629	lipid metabolic process
GO:0006640	monoacylglycerol biosynthetic process
GO:0006641	triglyceride metabolic process
GO:0019432	triglyceride biosynthetic process
GO:0019915	lipid storage
GO:0034379	very-low-density lipoprotein particle assembly
GO:0035336	long-chain fatty-acyl-CoA metabolic process
GO:0042572	retinol metabolic process
GO:0046339	diacylglycerol metabolic process
GO:0046486	glycerolipid metabolic process
GO:0055089	fatty acid homeostasis

	Cellular Component
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0035579	specific granule membrane
GO:0043231	intracellular membrane-bounded organelle

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External links

PDB	RCSB:6vz1, PDBe:6vz1, PDBj:6vz1
PDBsum	6vz1
PubMed	32433611
UniProt	O75907\|DGAT1_HUMAN Diacylglycerol O-acyltransferase 1 (Gene Name=DGAT1)

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