Structure of PDB 6vwc Chain B

Receptor sequence
>6vwcB (length=139) Species: 9606 (Homo sapiens) [Search protein sequence]
SQSNRELVVDFLSYKLSQKGYSAGGMAAVKQALREAGDEFELRYRRAFSD
LTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDK
KMQVLVSRIAAWMATYLNDHLEPWIQENGGWATFVELYG
3D structure
PDB6vwc Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-X L Inhibitor.
ChainB
Resolution1.604 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RQ7 B A93 F97 Y101 R102 F105 S106 L108 T109 E129 L130 R132 G138 R139 A142 S145 F146 A149 Y195 A36 F40 Y44 R45 F48 S49 L51 T52 E72 L73 R75 G81 R82 A85 S88 F89 A92 Y138 MOAD: Ki=5nM
BindingDB: Ki=205nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:6vwc, PDBe:6vwc, PDBj:6vwc
PDBsum6vwc
PubMed33062160
UniProtQ07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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