Structure of PDB 6vvo Chain B

Receptor sequence
>6vvoB (length=316) Species: 9606 (Homo sapiens) [Search protein sequence]
YELPWVEKYRPVKLNEIVGNEDTVSRLEVFAREGNVPNIIIAGPPGTGKT
TSILCLARALLGPALKDAMLELNASNDRGIDVVRNKIKMFAQQKVTLPKG
RHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQS
RCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQAL
NNLQSTFSGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILA
HLWHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNS
LLQMAGLLARLCQKTM
3D structure
PDB6vvo Structure of the human clamp loader bound to the sliding clamp: a further twist on AAA+ mechanism
ChainB
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS B V39 R43 I50 V51 G52 P78 G79 T80 G81 K82 T83 T84 N172 M229 R230 V6 R10 I17 V18 G19 P45 G46 T47 G48 K49 T50 T51 N139 M196 R197
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0019899 enzyme binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair
GO:0032508 DNA duplex unwinding
GO:1900264 positive regulation of DNA-directed DNA polymerase activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005663 DNA replication factor C complex
GO:0031390 Ctf18 RFC-like complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6vvo, PDBe:6vvo, PDBj:6vvo
PDBsum6vvo
PubMed
UniProtP35250|RFC2_HUMAN Replication factor C subunit 2 (Gene Name=RFC2)

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