Structure of PDB 6vuf Chain B

Receptor sequence
>6vufB (length=125) Species: 9606 (Homo sapiens) [Search protein sequence]
SNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKL
NLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKP
GDDIVLMAEALEKLFLQKINELPTE
3D structure
PDB6vuf Substituted 1-methyl-4-phenylpyrrolidin-2-ones - Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors.
ChainB
Resolution1.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RLV B W81 F83 V87 L92 C136 N140 W39 F41 V45 L50 C94 N98 MOAD: ic50=147uM
External links
PDB RCSB:6vuf, PDBe:6vuf, PDBj:6vuf
PDBsum6vuf
PubMed32120339
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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