Structure of PDB 6vue Chain B

Receptor sequence
>6vueB (length=801) Species: 207559 (Oleidesulfovibrio alaskensis G20) [Search protein sequence]
VPRGSHMGIPDGPTPRHVKLKENFLKQVPSITVQRAVAITKIAKENPGLP
KPLLRAKTFRYCCETAPLVIQDHELIVGSPNGAPRAGAFSPEVAWRWLQD
ELDTIGSRPQDPFYISEEDKKVLREEVFPFWQNKSVDEFCEGQYREADLW
EMSGESFVSDCSYHAVNGGGDSNPGYDVILMKKGMLDIQREAREKLEQLD
YANPEDIDKIYFYKSVIETAEGVMIYARRLSAYAAELAARETDPRRKAEL
QKISEVNARVPAHAPSNFWEAIQAVWTVESLLVVEENQTGMSIGRVDQYM
YPFYRADIDSGRLTEYEAFDLAGCMLVKMSEMMWITSEGASKFFAGYQPF
VNMCVGGVTREGHDATNDLTYMLMDAVRHVRIYQPTLATRVHNKSPQKYL
KKIVDVIRSGMGFPAVHFDDAHIKMMLAKGVSIEDARDYCLMGCVEPQKS
GRLYQWTSTGYTQWPICIELVLNHGVPLWYGKKVTPDMGDLSQYDTYEKF
EAAVKEQIRWITKNTSVATVISQRAHRELAPKPLMSLMYEGCMESGRDVS
AGGAMYNFGPGVVWSGLATYVDSMAAIKKLVYDDRKYTLAQLNEALKADF
AGYDQILADCLAAPKYGNDDDYADMIAADLVHFTETEHRKYKTLYSVLSH
GTLSISNNTPFGQLLGASANGRRAWMPLSDGISPTQGADYKGPTAIIKSV
SKMANDNMNIGMVHNFKLMSGLLDTPEGENGLITLIRTACMLGNGEMQFN
YLDNELLLDAQKHPEKYRDLVVRVAGYSAFFVELCKDVQDEIISRTMLHG
F
3D structure
PDB6vue Discovery of a Cyclic Choline Analog That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria.
ChainB
Resolution2.28 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F395 G488 C489 G821
Catalytic site (residue number reindexed from 1) F350 G443 C444 G776
Enzyme Commision number 4.3.99.4: choline trimethylamine-lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RP7 B Y208 D216 F395 C489 E491 T502 Y506 I700 Y163 D171 F350 C444 E446 T457 Y461 I655 MOAD: ic50=2.9uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016829 lyase activity
GO:0016840 carbon-nitrogen lyase activity
GO:0033265 choline binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0042426 choline catabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6vue, PDBe:6vue, PDBj:6vue
PDBsum6vue
PubMed33062182
UniProtQ30W70|CUTC_OLEA2 Choline trimethylamine-lyase (Gene Name=cutC)

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