Structure of PDB 6vty Chain B

Receptor sequence
>6vtyB (length=372) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
SYNPEFFLYDIFLKFCLKYIDGEICHDLFLLLGKYNILPYDTSNDSIYAC
TNIKHLDFINPFGVAAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTGNA
KPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEEDKLLSKHIVG
VSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGK
LKNIILSVKEEIDNLEKNNFLWFNTTKKKPLVFVKLAPDLNQEQKKEIAD
VLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAKLKDISTKFICEMYN
YTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQIKR
ELNHLLYQRGYYNLKEAIGRKH
3D structure
PDB6vty Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria.
ChainB
Resolution1.78 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N274 F278 S345 N347 T348 K429 N458
Catalytic site (residue number reindexed from 1) N115 F119 S186 N188 T189 K235 N264
Enzyme Commision number 1.3.5.2: dihydroorotate dehydrogenase (quinone).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RLA B Y168 L172 G181 C184 H185 L187 F188 I263 R265 V532 Y9 L13 G22 C25 H26 L28 F29 I104 R106 V338 MOAD: ic50=0.1uM
BS02 FMN B A225 G226 T249 N274 N342 K429 S477 G478 S505 G506 G507 Y528 S529 A66 G67 T90 N115 N183 K235 S283 G284 S311 G312 G313 Y334 S335
Gene Ontology
Molecular Function
GO:0004152 dihydroorotate dehydrogenase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:6vty, PDBe:6vty, PDBj:6vty
PDBsum6vty
PubMed32248693
UniProtQ08210|PYRD_PLAF7 Dihydroorotate dehydrogenase (quinone), mitochondrial (Gene Name=PFF0160c)

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