Structure of PDB 6vrf Chain B

Receptor sequence
>6vrfB (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
DILSVGILVKERWKVLRKIGGGEIYDALDMLTRENVALKVESAQQPKQVL
KMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRG
TFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYM
LDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWS
LFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSIFLDH
ISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWE
3D structure
PDB6vrf Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms.
ChainB
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B I35 A48 K50 M94 Q97 N100 S145 D163 I24 A37 K39 M83 Q86 N89 S134 D152
BS02 MG B N146 D163 N135 D152
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6vrf, PDBe:6vrf, PDBj:6vrf
PDBsum6vrf
PubMed32424773
UniProtQ6IQ55|TTBK2_HUMAN Tau-tubulin kinase 2 (Gene Name=TTBK2)

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