Structure of PDB 6vn4 Chain B

Receptor sequence
>6vn4B (length=342) Species: 9606 (Homo sapiens) [Search protein sequence]
GSKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKS
VPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLD
NVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIK
GKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQ
LMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLV
HSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHCTNA
YMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQKR
3D structure
PDB6vn4 Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity.
ChainB
Resolution2.69 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R4D B Y224 D295 Q297 L406 M407 R408 F409 K420 H456 H461 Y465 Y514 Y19 D90 Q92 L201 M202 R203 F204 K215 H251 H256 Y260 Y301 BindingDB: IC50=8200nM
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:6vn4, PDBe:6vn4, PDBj:6vn4
PDBsum6vn4
PubMed32302140
UniProtQ93009|UBP7_HUMAN Ubiquitin carboxyl-terminal hydrolase 7 (Gene Name=USP7)

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