Structure of PDB 6vlm Chain B

Receptor sequence
>6vlmB (length=149) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
SPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAG
RWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEDGIPYNPQSQGVVESMNK
ELKKIIGQVRDQAEHLKTAVQMAVFIHNHKRGYSAGERIVDIIATDIQT
3D structure
PDB6vlm Augmenting Hit Identification by Virtual Screening Techniques in Small Molecule Drug Discovery.
ChainB
Resolution2.32 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R2D B T125 A128 W132 T69 A72 W76 MOAD: ic50=10uM
BS02 R2D B A169 E170 H171 T174 A113 E114 H115 T118 MOAD: ic50=10uM
BS03 R2D B K127 A128 W131 K71 A72 W75 MOAD: ic50=10uM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:6vlm, PDBe:6vlm, PDBj:6vlm
PDBsum6vlm
PubMed32309939
UniProtP03367|POL_HV1BR Gag-Pol polyprotein (Gene Name=gag-pol)

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