Structure of PDB 6vji Chain B

Receptor sequence
>6vjiB (length=253) Species: 13616 (Monodelphis domestica) [Search protein sequence]
PSLRKFHQLVAPFVGQLVVTVGGNSKKINPNMLEMLRLQDSQVHGKNLYL
NFGLTEDLGLPESFLLPNSGLWLCFHFGLFGSVRASELSRATWKDPIPRL
VLHFAKGFLAFYNCRIYWCLGPTVKPTSDILSEEFDRRQALEALKQASPV
SYTLLDQRYFAGLGNIIKNEVLYLARIHPLSLGSCLTPLNLESLLDHVVS
FSVGWLQKKLEGKPLHHLIYQKEQCPAGHQVMKDSFGPFQRLTWWCPHCQ
PKA
3D structure
PDB6vji Unique Structural Features of Mammalian NEIL2 DNA Glycosylase Prime Its Activity for Diverse DNA Substrates and Environments.
ChainB
Resolution2.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C294 H298 C225 H229
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0016829 lyase activity
GO:0019104 DNA N-glycosylase activity
GO:0046872 metal ion binding
GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0015630 microtubule cytoskeleton
GO:0043231 intracellular membrane-bounded organelle
GO:0072686 mitotic spindle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6vji, PDBe:6vji, PDBj:6vji
PDBsum6vji
PubMed32846144
UniProtF7AMK3

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