Structure of PDB 6vi4 Chain B

Receptor sequence
>6vi4B (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTT
TMPFQSTVYLMNSWPFGDVLCKIVLSIDYYNMFTSIFTLTMMSVDRYIAV
CHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIEC
SLQDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSRE
KDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGALSSYYFCIALGYT
NSSLNPILYAFLDENFKRCFRDFCFP
3D structure
PDB6vi4 Nanobody-enabled monitoring of kappa opioid receptor states.
ChainB
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 JDC B W124 V134 D138 M142 V230 H291 Y320 W64 V74 D78 M82 V166 H227 Y249 BindingDB: Ki=0.030000nM,EC50=6nM
BS02 CLR B I158 H162 I98 H102
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004985 G protein-coupled opioid receptor activity
GO:0038048 dynorphin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:6vi4, PDBe:6vi4, PDBj:6vi4
PDBsum6vi4
PubMed32123179
UniProtP41145|OPRK_HUMAN Kappa-type opioid receptor (Gene Name=OPRK1)

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