Structure of PDB 6vff Chain B

Receptor sequence

>6vffB (length=436) Species: 9606 (Homo sapiens)

NPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLA
KARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGK
FGDLTDNFSSPHARRKVLAGVVMTTGTDVKDAKVISVSTGTKCINGEYMS
DRGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDDQKRSIFQKSERGGF
RLKENVQFHLYISTSPCGDARIFSPHEARGQLRTKIESGQGTIPVRSLTM
SCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRI
SNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINA
TTGKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKITKPNVYHESKLA
AKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSLT

3D structure

• PDB: 6vff Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition.
• Chain: B
• Resolution: 2.8 Å

Enzymatic activity

• Enzyme Commision number: 3.5.4.37: double-stranded RNA adenine deaminase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	B	S258 K261 F263 R279 N280 K281	S24 K27 F29 R45 N46 K47
BS02	rna	B	M238 H259 K282 K594	M4 H25 K48 K330
BS03	IHP	B	N391 I397 R401 K519 R522 G530 S531 K629 Y658 K662 Y668 K672 E689 K690	N157 I163 R167 K255 R258 G266 S267 K365 Y394 K398 Y404 K408 E425 K426
BS04	ZN	B	H394 C451 C516	H160 C217 C252

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004000 adenosine deaminase activity

Biological Process

• GO:0006396 RNA processing

External links

• PDB: RCSB:6vff, PDBe:6vff, PDBj:6vff
• PDBsum: 6vff
• PubMed: 32597966
• UniProt: P78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)