Structure of PDB 6vbi Chain B

Receptor sequence
>6vbiB (length=301) Species: 9606 (Homo sapiens) [Search protein sequence]
EETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNL
VQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKI
QNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHH
HFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGE
FFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVAT
EKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAE
Q
3D structure
PDB6vbi Identification of a novel allosteric pocket and its regulation mechanism
ChainB
Resolution2.30001 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FZA B M691 S695 M157 S161
BS02 FZA B D563 F564 A611 N614 R616 H617 N620 S766 A767 K770 I778 D29 F30 A77 N80 R82 H83 N86 S232 A233 K236 I244
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6vbi, PDBe:6vbi, PDBj:6vbi
PDBsum6vbi
PubMed
UniProtO76074|PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosphodiesterase (Gene Name=PDE5A)

[Back to BioLiP]