Structure of PDB 6vaa Chain B

Receptor sequence
>6vaaB (length=1153) Species: 9606 (Homo sapiens) [Search protein sequence]
DSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHPSYPKIIE
EFVSGLESYIEDEDSFRNCLLSCERLQSYSKSLIKLLLGIDILQPAIIKT
LFEKLPEYFFENKNSDEINIPRLIVSQLKWLDRVVDGKDLTTKIMQLISI
APENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSL
RLDPNFLLKVRQLVMDKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELR
EKLDLQHCVSSGQSCIILLFDVIKSAIRYEKTISEAWIKAIENTASVSEH
KVFDLVMLFIIYSTNTQTKKYIDRVLRNKIRSGCIQEQLLQSTFSVHYLV
LKDMCSSILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGAL
VTHICSGNEAEVDTALDVLLELVVLNPSAMMMNAVFVKGILDYLDNISPQ
QIRKLFYVLSTLAFSKQNEASSHIQDDMHLVIRKQLSSTVFKYKLIGIIG
AVTMAGIMAADEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQHEK
LDPKALEWVGQTICNDFQDAFVVDSCVVPEGDFPFPVKALYGLEEYDTQN
GIAINLLPLLFSQDSPLCLAPYFRLLRLCVERQHNGNLEEIDGLLDCPIF
LTDLEPGEKLESMSAKERSFMCSLIFLTLNWFREIVNAFCQETSPEMKGK
VLTRLKHIVELQIILEKYLAVTPDYVPPLGNFDVETLDITLLLHNSHAFF
RELDIEVFSILHCGLVTKFILLGPPELLFLLEDLSQKLESMLTFSHLQQR
SAQEIVHCVFQLLTPMCNHLENIHNYFQCLAAENHKVQEYHIMSSCYQRL
LQIFHGLFAWSGFSQPENQNLLYSALHVLSSRLKQGEHSQPLEELLSQSV
HYLQNFHQSIPSFQCALYLIRLLMVILEKSQNKEKIASLARQFLCRVWPS
GDKEKSNISNDQLHALLCIYLEHTESILKAIEEIAGVGVPELINSPSSTF
PTLTRHTFVVFFRVMMAELEKTVKKIEPGTAADSQQIHEEKLLYWNMAVR
DFSILINLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMPLLDFSFRKHRED
VLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPLLKKTLELLVCRVKA
MLT
3D structure
PDB6vaa DNA clamp function of the monoubiquitinated Fanconi anaemia ID complex.
ChainB
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B N1179 R1236 H1292 K1296 N960 R1013 H1069 K1073
BS02 dna B H1229 R1352 H1006 R1129
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0070182 DNA polymerase binding
Biological Process
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0007129 homologous chromosome pairing at meiosis
GO:0007276 gamete generation
GO:0010332 response to gamma radiation
GO:0031573 mitotic intra-S DNA damage checkpoint signaling
GO:0034599 cellular response to oxidative stress
GO:0036297 interstrand cross-link repair
GO:0045589 regulation of regulatory T cell differentiation
GO:0048854 brain morphogenesis
GO:0050727 regulation of inflammatory response
GO:0097150 neuronal stem cell population maintenance
GO:1990918 double-strand break repair involved in meiotic recombination
GO:2000348 regulation of CD40 signaling pathway
Cellular Component
GO:0000785 chromatin
GO:0000793 condensed chromosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0016604 nuclear body
GO:1990391 DNA repair complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6vaa, PDBe:6vaa, PDBj:6vaa
PDBsum6vaa
PubMed32269332
UniProtQ9BXW9|FACD2_HUMAN Fanconi anemia group D2 protein (Gene Name=FANCD2)

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