Structure of PDB 6v8t Chain B

Receptor sequence
>6v8tB (length=214) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLTADQMVSALLDAEPPILYSEYPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLL
DRNQVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYDHIH
RVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLY
SNVVPLSDLLLEML
3D structure
PDB6v8t Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C6V B L346 T347 A350 E353 F404 M421 L428 G521 L525 N532 V533 L36 T37 A40 E43 F94 M108 L115 G195 L199 N202 V203 BindingDB: IC50=6.0nM
External links
PDB RCSB:6v8t, PDBe:6v8t, PDBj:6v8t
PDBsum6v8t
PubMed35575456
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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