Structure of PDB 6v2u Chain B

Receptor sequence
>6v2uB (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNTPQQLQAFKNEV
GVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIK
LIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLSILWM
APEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVG
RGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
3D structure
PDB6v2u Crystal structure of the insect cell-expressed WT-BRAF kinase in complex with Dabrafenib
ChainB
Resolution3.78 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D576 K578 N580 N581 D594 S616
Catalytic site (residue number reindexed from 1) D124 K126 N128 N129 D142 S146
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P06 B S465 V471 K483 L505 L514 F516 T529 W531 C532 F583 D594 F595 S17 V23 K35 L53 L62 F64 T77 W79 C80 F131 D142 F143 BindingDB: IC50=1.000000nM,EC50=529nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6v2u, PDBe:6v2u, PDBj:6v2u
PDBsum6v2u
PubMed
UniProtP15056|BRAF_HUMAN Serine/threonine-protein kinase B-raf (Gene Name=BRAF)

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