Structure of PDB 6uyb Chain B

Receptor sequence
>6uybB (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
AWQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQGAPPLESVDV
RQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGGFYGVSSQYESL
EHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNF
LHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERG
AQHHIYRLVR
3D structure
PDB6uyb Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling.
ChainB
Resolution1.543 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QSJ B F233 F251 V329 K357 P378 C380 L383 L387 I408 Q410 Y426 F428 F17 F35 V93 K121 P142 C144 L147 L151 I172 Q174 Y190 F192 MOAD: Kd=6.2uM
External links
PDB RCSB:6uyb, PDBe:6uyb, PDBj:6uyb
PDBsum6uyb
PubMed32579935
UniProtQ15562|TEAD2_HUMAN Transcriptional enhancer factor TEF-4 (Gene Name=TEAD2)

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