Structure of PDB 6uw2 Chain B

Receptor sequence
>6uw2B (length=447) Species: 1257118 (Acanthamoeba castellanii str. Neff) [Search protein sequence]
GKLPPVVSSLIPFVGSGLSFAGGPLQYTTDAYKKYGDIFTMKVFGQRLTF
LVGPDAHVPFFSQGDAELSQDEPYQFSVPIFGPNVVYGADLAHRNQQLKF
IAASLSTKALQSYVPLIVKEAEDFFAKWDKSGTVDIRDALAELIILTASR
CLMGKEIRENLFTEVAKLYQTLDEGLLPISVFFPYLPIPAHKRRDEARLA
MVRMFKKIIDERRANPEVKHNDCLQVFMDARYRGEEQALNDEEITGLMIA
LLFAGQHTSSVTGSWTGLLLFEANNKKKFLPGVLEEQEEIRKEFGDELTM
EALNKMDKLHRCVKEALRMYPPLLFVMRKVIKPFSYKDYYVPEGDTVFVS
PALSMRVEEVFPNADQYNPERFVEEDKQAQKYRFVGFGAGRHGCMGENFA
YLQIKTIWSVLLRNFDIELVGELPKPDYTAMVVGPAHPCLLRYTRKH
3D structure
PDB6uw2 Domain-Swap Dimerization of Acanthamoeba castellanii CYP51 and a Unique Mechanism of Inactivation by Isavuconazole.
ChainB
Resolution2.92 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM B Q110 Y114 L145 L291 A294 T298 S299 R368 G426 F427 H432 C434 G436 F439 Q70 Y74 L105 L251 A254 T258 S259 R328 G386 F387 H392 C394 G396 F399
BS02 CL6 B Y114 A290 F293 A294 T298 Y74 A250 F253 A254 T258
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008168 methyltransferase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0032259 methylation
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6uw2, PDBe:6uw2, PDBj:6uw2
PDBsum6uw2
PubMed33008918
UniProtL8GJB3

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