Structure of PDB 6uns Chain B

Receptor sequence
>6unsB (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
VARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYN
TVMLRHENILGFIASDMTSRSSTQLWLITHYHEMGSLYDYLQLTTLDTVS
CLRIVLSIASGLAHLHIEIFGGKPAIAHRDLKSKNILVKKNGQCCIADLG
LAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWA
FGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPN
IPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIAATLT
3D structure
PDB6uns Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization.
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LDN B V214 V222 A233 L263 T283 H284 Y285 H286 E287 G289 L343 A353 V11 V19 A30 L60 T79 H80 Y81 H82 E83 G85 L137 A147 BindingDB: IC50=17nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6uns, PDBe:6uns, PDBj:6uns
PDBsum6uns
PubMed34400635
UniProtQ04771|ACVR1_HUMAN Activin receptor type-1 (Gene Name=ACVR1)

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