Structure of PDB 6unp Chain B

Receptor sequence

>6unpB (length=303) Species: 9606 (Homo sapiens)

SLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNI
YRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS
DWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGT
CVISDFGLSMRLTGNRLVRPSEVGTIRYMAPEVLEGAVNLRDCESALKQV
DMYALGLIYWEIFMRCTDLFPSVPEYQMAFQTEVGNHPTFEDMQVLVSRE
KQRPKFPEAWKENSLAVRSLKETIEDCWGQDAEARLTAQCAEERMAELMM
IWE

3D structure

• PDB: 6unp Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization.
• Chain: B
• Resolution: 2.3 Å

Enzymatic activity

• Enzyme Commision number: 2.7.11.30: receptor protein serine/threonine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	B	I209 G210 G212 Y214 G215 V217 A228 K230 M279 Y282 R337 L340 D351	I13 G14 G16 Y18 G19 V21 A32 K34 M83 Y86 R141 L144 D155
BS02	MG	B	N338 D351	N142 D155
BS03	MG	B	P226 E280 Y281	P30 E84 Y85
BS04	MG	B	E243 Y247 M279 D351	E47 Y51 M83 D155
BS05	MG	B	H294 T295 S296	H98 T99 S100
BS06	MG	B	H316 T493 A494	H120 T287 A288
BS07	MG	B	S301 I416 R419	S105 I212 R215
BS08	MG	B	E318 E398	E122 E194

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004675 transmembrane receptor protein serine/threonine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation
• GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6unp, PDBe:6unp, PDBj:6unp
• PDBsum: 6unp
• PubMed: 34400635
• UniProt: Q13873|BMPR2_HUMAN Bone morphogenetic protein receptor type-2 (Gene Name=BMPR2)