Structure of PDB 6ukz Chain B

Receptor sequence
>6ukzB (length=178) Species: 9606,559292 [Search protein sequence]
SVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLP
LDCGVPDNLSMADPNIRFLDKLPQQTADRAGIKDRVYSNSIYELLENGQR
AGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCQTLEDILADAP
ESQNNCRLIAYQEPSFSLSQEVLRHLRQ
3D structure
PDB6ukz An orally available non-nucleotide STING agonist with antitumor activity.
ChainB
Resolution1.52 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QBG B S162 Y163 Y167 R238 T263 P264 S9 Y10 Y14 R85 T110 P111
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0031386 protein tag activity
GO:0042802 identical protein binding
GO:0044389 ubiquitin-like protein ligase binding
Biological Process
GO:0002218 activation of innate immune response
GO:0016925 protein sumoylation
GO:0032481 positive regulation of type I interferon production
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0005634 nucleus
GO:0005940 septin ring

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Cellular Component
External links
PDB RCSB:6ukz, PDBe:6ukz, PDBj:6ukz
PDBsum6ukz
PubMed32820094
UniProtQ12306|SMT3_YEAST Ubiquitin-like protein SMT3 (Gene Name=SMT3);
Q86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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