Structure of PDB 6uk1 Chain B

Receptor sequence
>6uk1B (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
DIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKS
TLLLAFLRLLNTEGEIQIDGVSWDSITLEQWRKAFGVIPQDVFIFSGTFR
KNLDPNEQWSDQEIWKVADEVGLRSVIEQFPGGLDFVLVDGGCVLSHGHK
QLMCLARAVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCE
ARIEAMLECDQFLVIEENKVRQYDSIQK
3D structure
PDB6uk1 Mutational stabilization of the second nucleotide binding domain (NBD2) of CFTR yields soluble protein and insight into NBD2 disease-causing mutations
ChainB
Resolution2.693 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP B Y1219 I1226 T1246 G1247 G1249 K1250 S1251 T1252 Y18 I25 T45 G46 G48 K49 S50 T51
BS02 MG B S1251 D1370 E1371 S50 D169 E170
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:6uk1, PDBe:6uk1, PDBj:6uk1
PDBsum6uk1
PubMed
UniProtP13569|CFTR_HUMAN Cystic fibrosis transmembrane conductance regulator (Gene Name=CFTR)

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