Structure of PDB 6uj1 Chain B

Receptor sequence
>6uj1B (length=357) Species: 9606 (Homo sapiens) [Search protein sequence]
FLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYI
DTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVN
IATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPN
VFSMQMCGAGLNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEI
GGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLISDGF
WTGSQLACWTNETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMECY
RFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEI
SGPFNCV
3D structure
PDB6uj1 A Structure-Based Discovery Platform for BACE2 and the Development of Selective BACE Inhibitors.
ChainB
Resolution3.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.23.45: memapsin 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 L3M B L46 D48 Y87 T88 Q89 F124 W131 Y211 D241 G243 T244 T245 L246 R248 S337 L32 D34 Y73 T74 Q75 F110 W117 Y190 D220 G222 T223 T224 L225 R227 S305
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6uj1, PDBe:6uj1, PDBj:6uj1
PDBsum6uj1
PubMed33544569
UniProtQ9Y5Z0|BACE2_HUMAN Beta-secretase 2 (Gene Name=BACE2)

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