Structure of PDB 6uib Chain B

Receptor sequence
>6uibB (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
LIWELKKDVYVVELDAPGEMVVLTCDWTLDQSSEVLGSGKTLTIQVKEFG
DAGQYTCHHSLLLLHKKEDGIWSTDILKDQNKTFLRCEAKNYSGRFTCWW
LTTISTDLTFSVKSSRGSSDPQGVTCGAATLSAERVEYEYSVECQEDSAC
PAAEESLPIEVMVDAVHKLKYENYTSSFFIRDIIKPDPPKNLQLKPLKNS
RQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKSKKKDRVFTDKTSATVICR
KSISVRAQDRYYSSSWSEWASVPC
3D structure
PDB6uib Integration of phage and yeast display platforms: A reliable and cost effective approach for binning of peptides as displayed on-phage.
ChainB
Resolution2.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 peptide B T250 F268 T269 Q289 R291 S294 W297 T223 F239 T240 Q258 R260 S263 W266
Gene Ontology
Molecular Function
GO:0004896 cytokine receptor activity
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005143 interleukin-12 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0019955 cytokine binding
GO:0042164 interleukin-12 alpha subunit binding
GO:0042802 identical protein binding
GO:0044877 protein-containing complex binding
GO:0045519 interleukin-23 receptor binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001817 regulation of cytokine production
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002230 positive regulation of defense response to virus by host
GO:0002323 natural killer cell activation involved in immune response
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0007166 cell surface receptor signaling pathway
GO:0007259 cell surface receptor signaling pathway via JAK-STAT
GO:0008283 cell population proliferation
GO:0010224 response to UV-B
GO:0016477 cell migration
GO:0019221 cytokine-mediated signaling pathway
GO:0019953 sexual reproduction
GO:0030101 natural killer cell activation
GO:0032693 negative regulation of interleukin-10 production
GO:0032700 negative regulation of interleukin-17 production
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 positive regulation of type II interferon production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032740 positive regulation of interleukin-17 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032816 positive regulation of natural killer cell activation
GO:0032819 positive regulation of natural killer cell proliferation
GO:0032946 positive regulation of mononuclear cell proliferation
GO:0034105 positive regulation of tissue remodeling
GO:0034393 positive regulation of smooth muscle cell apoptotic process
GO:0035722 interleukin-12-mediated signaling pathway
GO:0042088 T-helper 1 type immune response
GO:0042093 T-helper cell differentiation
GO:0042098 T cell proliferation
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042832 defense response to protozoan
GO:0043382 positive regulation of memory T cell differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045785 positive regulation of cell adhesion
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050709 negative regulation of protein secretion
GO:0050729 positive regulation of inflammatory response
GO:0050829 defense response to Gram-negative bacterium
GO:0051135 positive regulation of NK T cell activation
GO:0051142 positive regulation of NK T cell proliferation
GO:0051607 defense response to virus
GO:0071222 cellular response to lipopolysaccharide
GO:0071346 cellular response to type II interferon
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway
GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction
GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:2000318 positive regulation of T-helper 17 type immune response
GO:2000330 positive regulation of T-helper 17 cell lineage commitment
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0005829 cytosol
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0031906 late endosome lumen
GO:0043235 receptor complex
GO:0043514 interleukin-12 complex
GO:0070743 interleukin-23 complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:6uib, PDBe:6uib, PDBj:6uib
PDBsum6uib
PubMed32479512
UniProtP29460|IL12B_HUMAN Interleukin-12 subunit beta (Gene Name=IL12B)

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