Structure of PDB 6uhc Chain B

Receptor sequence

>6uhcB (length=374) Species: 9606 (Homo sapiens) [Search protein sequence]

RKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIREIKDLMVGDEASE
LRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPP
MNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGV
THICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETV
RMIKEKLCYVGYNIEQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPE
ALFQHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLP
SRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAVLADI
MKDKDNFWMTRQEYQEKGVRVLEK

3D structure

PDB

6uhc Cryo-EM structure of NPF-bound human Arp2/3 complex and activation mechanism.

Chain

Resolution

3.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	Y147 G150 R343 M365	Y134 G137 R329 M351
BS02	ATP	B	D161 E218 G306	D148 E205 G292

Gene Ontology

	Molecular Function
GO:0003779	actin binding
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0051015	actin filament binding

	Biological Process
GO:0007163	establishment or maintenance of cell polarity
GO:0008356	asymmetric cell division
GO:0010592	positive regulation of lamellipodium assembly
GO:0016344	meiotic chromosome movement towards spindle pole
GO:0016482	cytosolic transport
GO:0030036	actin cytoskeleton organization
GO:0033206	meiotic cytokinesis
GO:0034314	Arp2/3 complex-mediated actin nucleation
GO:0045944	positive regulation of transcription by RNA polymerase II
GO:0051321	meiotic cell cycle
GO:0051653	spindle localization
GO:0060271	cilium assembly
GO:0071346	cellular response to type II interferon
GO:1905168	positive regulation of double-strand break repair via homologous recombination
GO:2001032	regulation of double-strand break repair via nonhomologous end joining

	Cellular Component
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005885	Arp2/3 protein complex
GO:0005925	focal adhesion
GO:0005938	cell cortex
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0030478	actin cap
GO:0035578	azurophil granule lumen
GO:0035861	site of double-strand break
GO:0042995	cell projection
GO:0070062	extracellular exosome
GO:1904813	ficolin-1-rich granule lumen

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6uhc, PDBe:6uhc, PDBj:6uhc
PDBsum	6uhc
PubMed	32548263
UniProt	P61160\|ARP2_HUMAN Actin-related protein 2 (Gene Name=ACTR2)

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