Structure of PDB 6u9m Chain B

Receptor sequence
>6u9mB (length=149) Species: 9606 (Homo sapiens) [Search protein sequence]
DLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGIV
IRSILTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPN
CYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFKLPCNCGAKKCRKFL
3D structure
PDB6u9m Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase.
ChainB
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y3858 Y3944
Catalytic site (residue number reindexed from 1) Y46 Y132
Enzyme Commision number 2.1.1.-
2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C3909 C3957 C3959 C97 C138 C140
BS02 Q2M B I3838 H3839 R3841 Y3883 F3904 N3906 H3907 Y3944 C3957 N3958 I26 H27 R29 Y71 F92 N94 H95 Y132 C138 N139 MOAD: ic50=66.5nM
External links
PDB RCSB:6u9m, PDBe:6u9m, PDBj:6u9m
PDBsum6u9m
PubMed32551023
UniProtQ03164|KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Gene Name=KMT2A)

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