Structure of PDB 6u6x Chain B

Receptor sequence
>6u6xB (length=383) Species: 9606 (Homo sapiens) [Search protein sequence]
MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNR
FEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFS
HMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED
ICFIKEQIVGLWPYKGRPENKSFLYEIVSNKRNGIDVAKWDYFARDCHHL
GIQNNFDYKRFIKFARVICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNI
IDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEIL
YSTDPKLKDAREILKQIEYRNLFKKIKREDYESLPKEVASAKPKVLEDFI
VDVINMLIRVYCKKVDRKSLYAARQYFVQWCAD
3D structure
PDB6u6x Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.
ChainB
Resolution2.58 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B Y155 V156 R372 H376 R451 Y41 V42 R241 H245 R320
BS02 dna B K116 V117 N119 H125 D137 Q142 R145 K2 V3 N5 H11 D23 Q28 R31
BS03 ZN B H167 D207 H53 D93
External links
PDB RCSB:6u6x, PDBe:6u6x, PDBj:6u6x
PDBsum6u6x
PubMed33531504
UniProtQ9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

[Back to BioLiP]